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DamrixPlastics

Industries · DMX-IND-02

Pharmaceutical grade materials with documentation for change control

Materials for validated production and packaging environments, where a grade change is a documented event. Selection is driven by biocompatibility class, extractables and leachables profile, sterilisation method and the retention of lot-level records your quality system requires.

Standards
USP VI · ISO 10993
Sterilisation
Steam · EtO · gamma
Supply chain
ISO 13485:2016
Record retention
7 years

Supply chain standards

The standards we require from our supply chain

Biocompatibility and quality-system conformity are held by the certified manufacturing partners producing the stock. We require current certification and grade-level test data on file before a material is offered into a validated environment.

USP Class VIGrade dependentISO 10993Grade dependentFDA 21 CFR 177Grade dependentISO 13485:2016Partner certifiedISO 9001:2015Partner certifiedFDA-RegisteredPartner facilities

Certifications listed are held by certified manufacturing partners in our supply chain. Damrix is a distributor and does not hold manufacturing certification.

Standard applicabilitySTD-MATRIX / 04
USP Class VIBiological reactivity, in vivo
ISO 10993-4/5/6Haemolysis · cytotoxicity · implant
ISO 13485:2016Medical device QMS — partner held
FDA 21 CFR 177Indirect food additives — polymers
Extractables dataPartner-issued, per grade
Animal-origin statementTSE / BSE-free on request
Change notificationGrade or source change flagged

Sector requirements

What a validated environment demands of a material

A material entering a validated process carries an administrative burden alongside the technical one. Both are addressed before the first order.

REQ 01

Biocompatibility class

USP Class VI or ISO 10993 test data must exist for the specific grade and be traceable to the resin lot, not asserted at the family level.

REQ 02

Sterilisation survival

Repeat autoclave, EtO or gamma exposure degrades some polymers. PEEK, PEI and PPSU are specified where cycle counts run into the hundreds.

REQ 03

Extractables profile

Low-extractables grades are required for fluid-path and product-contact service. Additive and pigment packages are disclosed on request.

REQ 04

Change control

Grade substitutions and upstream source changes are notified in writing so your validation status is never altered without a record.

Qualifying materials

Grades applied in this sector

Grades below are carried with biocompatibility or fluid-path documentation available on selected variants. Medical and high-purity grades are identified by grade code, not by family.

Documentation

What ships with the material

Every document is issued against the lot shipped so it can be filed directly against a validated process without a secondary request cycle.

Document packageDOC-SET / REV 04
Certificate of conformanceEvery order
Certificate of analysisPer lot, on request
USP Class VI test summaryQualifying grades
ISO 10993 test summaryQualifying grades
Resin lot traceabilityRecorded per shipment
TSE / BSE statementOn request
RoHS / REACH declarationOn request
Change notificationWritten, in advance

Next step

Review a validated-environment requirement

Send the application, sterilisation method, biocompatibility class required and the documentation your quality system needs on file. We confirm qualifying grades and data availability.